The doctors say that darzalex goes to work quickly because it targets the cancer cells. I'm no oncologist but I do know that finally my blood counts are going up and creatinine is dropping. Hemoglobin is 10.8 which means no procrit shot for first time in a couple of months. Creatinine is 2.82, meaning my kidneys are definitely out of failure territory. So I'd say something is going on.